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I did not know this ammunition. In this a picture is worth a lot of wordsAmmo. I got some of these for sd. For ultra concealed carry.. Haven't tested them yet.
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Stunning!Without knowing why the OP wants a handgun we're just guessing here. Here is a pic of my S&W Model 41, just because I like it.
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My absolute favorite 22 handgun.It really depends on what you're going to use it for and what fits & works for you. Any of the ones on your list would probably be fine as long as they fit you well and serve your purpose. You might consider renting some to try out. Oak Ridge range in Gulf Breeze/Midway rents guns, but I don't know what .22s they have to rent. If I had to choose one on the linked list, it'd be the Ruger Mark IV.
For me, my favorite target .22 is my S&W Model 41, but these are fairly heavy (for a .22) and quite pricey nowadays. For simple plinking/target fun, I think the ATI/GSC 1911 .22s are hard to beat for the price, but hey, I'm a 1911 kind of guy so YMMV. They are made in Germany and mine (I have 2) have functioned perfectly. Prices and availability vary online, but I paid less than $240 each for mine. They are very light, and the first time I pulled the slide back on one, it was so easy I thought they'd forgotten to install the recoil spring. Good luck finding the perfect one for you.
The ATI/GSG comes in Black, two-tone Black & Silver, and Tan. Here is one of mine...(my other one is the 2-tone)...
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Where is the drool emoji...If it were for self defense I would look into a better quality revolver with shorter barrel and medium or smaller frame. Some revolvers come with 10 shot cyclinders. For self defense with rimfire cartridges, the revolver does have an edge. If the cartridge does not fire a pull of the trigger and that chamber is out of the way to fire the next one in line.
I have an S&W 41 and they are often not happy with many brands of low velocity ammo. Mine will handle CCI standard velocity, but not Aguila standard velocity that shoots fine in other pistols. I think they sell for about $1,300 or so these days.
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For me the Ruger 512's. With 5.5" heavy bbl they seem to balance perfect. Either in the standard grip or the 22/45 grip.
Perfect training gun also. ---- SAWMAN